How many ELNs are optimal for breast cancer patients with more than three PLNs who underwent MRM? A large population-based study
نویسندگان
چکیده
Background Few studies have focused on the optimal threshold of examed lymph nodes (ELNs) for breast cancer patients with more than three positive lymph nodes after modified radical mastectomy. Materials and methods The X-tile and the minimum P-value models were applied to determine the optimal threshold. Cox proportional hazard analysis was used to analyze the cancer-specific survival and perform subgroup analysis. Results The results showed that 12 ELNs was the optimal threshold for these patients, and the patients with >12 ELNs had a better cancer-specific survival benefit compared with the patients with <12 ELNs (P<0.001). Conclusion The number 12 can be selected as the optimal threshold of ELNs for breast cancer patients with >3 positive lymph nodes after modified radical mastectomy.
منابع مشابه
The appropriate number of ELNs for lymph node negative breast cancer patients underwent MRM: a population-based study
Whether number of examed lymph nodes (ELNs) would bring survival benefit for patients with negative lymph nodes after modified radical mastectomy (MRM) is uncertain. In our study, using the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2009, we screened the appropriate patients with negative lymph nodes underwent MRM. The Cox proportional hazard analysis was used to...
متن کاملAssociation of tumor infiltration lymphocytes and complete pathological response in breast cancer patients under neoadjuvant chemotherapy
Background: The breast cancer is the most common type of cancer in Iran. Hence determination of the optimal treatment and the contributing factors are important. The main aim in current study was to determine the association between tumor infiltration of lymphocytes (TIL) and complete pathological response in breast cancer patients after neoadjuvant chemotherapy. Methods and materials: In this...
متن کاملEstimation of the thyroid secondary cancer risk on the patient of standard breast external beam radiotherapy
Introduction: The purpose of this study was to estimate the secondary cancer risk of thyroid for standard radiotherapy methods which are commonly used for breast cancer patients. Materials and Methods: Sixty-four breast cancer patients (their age range was around 50 years old) who referred to Seyed- Al- Shohada hospital (Isfahan, Iran) were included in this ...
متن کاملCompare the organs at risk in breast-conserving three- dimensional conformal radiotherapy (3D-CRT) based on patient's breast size
Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...
متن کاملCompare the organs at risk in breast-conserving three- dimensional conformal radiotherapy (3D-CRT) based on patient\'s breast size
Introduction: Breast cancer is the most common cancer among women. Radiotherapy plays an important role in the treatment of breast cancer and essential part of the standard treatment after breast-conserving surgery, routinely done to eliminate the microscopic residual cancer. The heart and lungs are one of the most important organs at risk of breast cancer radiotherapy that th...
متن کامل